Pyrrolopyrimidines

Details Pyrrolopyrimidines Pyrrolopyrimidines

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/529 (2006.01) A61P 35/02 (2006.01) C07D 498/08 (2006.01)

Patent

CA 2693715

The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to compounds that are polo-like kinase (PLKs) inhibitors useful for the treatment of disease states mediated by PLK, especially PLK4, in particular such compounds that are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumour growth, rheumatoid arthritis, restenosis and atherosclerosis.

La présente invention porte sur des composés ou des sels pharmaceutiquement acceptables de ceux-ci, sur des procédés permettant de les préparer, sur des compositions pharmaceutiques les contenant et sur leur utilisation en thérapie. L'invention porte particulièrement sur des composés qui sont des inhibiteurs de kinases de type polo (PLK), utiles pour le traitement d'états de maladie à médiation par PLK, notamment PLK4, en particulier sur de tels composés qui sont utiles dans le traitement de processus pathologiques qui mettent en jeu une prolifération cellulaire aberrante, telle qu'une croissance tumorale, l'arthrite rhumatoïde, la resténose et l'athérosclérose.

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