Pyrrolopyrimidines as protein kinase inhibitors

Details Pyrrolopyrimidines as protein kinase inhibitors Pyrrolopyrimidines as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) C07F 9/6561 (2006.01) C07F 9/6584 (2006.01)

Patent

CA 2344249

Chemical compounds having structural formula (I) and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatoid arthritis, disorders of the immune system, transplant rejections and imflammatory disorders.

L'invention concerne des composés chimiques, représentés par la formule développée (I), ainsi que des sels et des métabolites physiologiquement acceptables de ces composés. Ces composés inhibent l'activité des sérine/thréonine kinases et des tyrosine kinases. Plusieurs de ces kinases, dont l'activité est inhibée par ces composés, jouent un rôle dans des processus immunologiques, hyperprolifératifs, ou angiogéniques. Les composés de l'invention peuvent, de ce fait, améliorer des états pathologiques, pour lesquels l'angiogenèse ou l'hyperprolifération des cellules endothéliales constituent un facteur. Ces composés peuvent être utilisés pour le traitement du cancer, des troubles hyperprolifératifs, de la polyarthrite rhumatoïde, des dysfonctionnement du système immunitaire, des rejets du greffon, et des troubles inflammatoires.

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