Pyrrolopyrimidines, their production and use

Details Pyrrolopyrimidines, their production and use Pyrrolopyrimidines, their production and use

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 471/04 (2006.01) A61K 31/505 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2017604

ABSTRACT OF THE DISCLOSURE A compound of the formula (I) Image (I) wherein the ring Image may be hydrogenated, X is an amino, hydroxyl or mercapto group, Y is a hydrogen atom or a hydroxyl group, R1, R2, R4 and R5 are each a hydrogen atom, a lower hydrocarbon radical or a chemical bond, Z is -O-, a group of the formula -S(O)n- (n is 0 to 2), or a group of the formula Image in which R3 is a hydrogen atom, a lower hydrocarbon radical optionally having substituent(s), a group attached through -CO- or -S(O)m (m is 1 or 2) or a chemical bond, Image is a divalent cyclic group optionally having substituent(s) or a lower alkylene group optionally having substituent(s), -COOR6 and -COOR7 are each a carboxyl group optionally esterified, and i and j are an integer of 0 to 3 provided that i + j= 1 to 3, or its salt, which is useful as antitumor agent.

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