C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/241
C07D 471/06 (2006.01) C07D 487/06 (2006.01) C07D 498/06 (2006.01) C07D 513/06 (2006.01)
Patent
CA 1335592
Compounds of the formula Image I wherein the broken line represents no or a chemical bond; X is O, S, CH2 or CH2CH2; R1 is selected from the group consisting of hydrogen, halogen, C1-C6 alkoxy, C1-C6 alkanoyl, C1-C6 alkyl, and C1-C6 alkyl substituted with 1, 2 or 3 halogen atoms; R2 is selected from the group consisting of phenyl, substituted phenyl, heterocyclic groups, and substituted heterocyclic groups, said substituted phenyl and substituted heterocyclic groups being substituted with 1 or 2 substituents independently selected from the group consisting of C1-C6 alkyl, trifluoromethyl, and halogen; R3 and R4 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl,or trifluoromethyl, or R3 and R4, taken together with the carbon atoms to which they are attached, form a six-membered carbocyclic aromatic ring, said aromatic ring being optionally substituted with one or two substituents selected from the group consisting of halogen, C1-C6 alkyl, and C1-C6 alkyl substituted with 1, 2 or 3 halogen atoms; and the pharmaceutically acceptable salts thereof. The compounds are useful in treating inflammation or other prostaglandin or leukotriene mediated diseases.
593185
Lombardino Joseph George
Mcmanus James Michael
Mylari Banavara Lakshmana
Limited Pfizer
Smart & Biggar
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