C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2552107
The present invention provides compounds of formula (I); and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
La présente invention concerne des composés de formule (I) ; ainsi que des sels pharmaceutiquement acceptables de ces derniers. Lesdits composés de formule (I) inhibent l'activité tyrosine kinase des récepteurs de facteurs de croissance tels que HER1, HER2 et HER4, les rendant ainsi utiles en tant qu'agents antiprolifératifs. Lesdits composés de formule (I) sont également utiles pour le traitement d'autres maladies associées aux voies de transduction du signal fonctionnant par l'intermédiaire de récepteurs des facteurs de croissance.
Chen Ping
Fink Brian E.
Gavai Ashvinikumar V.
Han Wen-Ching
Mastalerz Harold
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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