Pyrrolotriazine inhibitors of kinases

Details Pyrrolotriazine inhibitors of kinases Pyrrolotriazine inhibitors of kinases

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/53 (2006.01)

Patent

CA 2373990

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making themuseful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

La présente invention concerne des composés de la formule (I) ainsi que leur sels acceptables sur le plan pharmaceutique. Les composés de la formule (I) inhibent l'activité tyrosine kinase des récepteurs de facteurs de croissance tels que VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, les rendant ainsi utiles en tant qu'agents anticancéreux. Les composés de la formule (I) sont également utiles dans le traitement d'autres maladies associées aux voies de transduction de signal opérant à travers les récepteurs de facteurs de croissance.

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