Pyrrolotriazolopyrimidinone derivatives

Details Pyrrolotriazolopyrimidinone derivatives Pyrrolotriazolopyrimidinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/519 (2006.01) A61P 9/00 (2006.01) A61P 15/00 (2006.01) C07D 209/00 (2006.01) C07D 239/00 (2006.01) C07D 249/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2417784

This invention relates to new therapeutically useful 8-(disubstituted)phenyl- 6,9-dihydro-5H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine-5-one and 8- phenyl-6,9-dihydro-5H-pyrrolo[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine-5-one derivatives of formula (I): wherein: -X-C-Y- represents (a) or (b) to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medical uses as potent and selective inhibitors of phosphodiesterase 5 (PDE 5).

L'invention concerne de nouveaux dérivés à usage thérapeutique : de 8-phényl(disubstitué)-6,9-dihydro-5<I>H</I>-pyrrolo[2,3-e][1,2,4]triazolo[4,3-c]pyrimidin-5-one et de 8-phényl-6,9-dihydro-5<I>H</I>-pyrrolo[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-5-one de formule (I) dans laquelle -X-C-Y- représentent (a) ou (b). L'invention concerne également des procédés et des intermédiaires pour la préparation desdits dérivés, des compositions pharmaceutiques contenant ces derniers, et leurs utilisations médicales en tant qu'inhibiteurs efficaces et sélectifs de la phosphodiestérase 5 (PDE 5).

Affiliated with

Also associated with

Rating

Pyrrolotriazolopyrimidinone derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrrolotriazolopyrimidinone derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrolotriazolopyrimidinone derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1962553