Pyrrolyl substituted pyrido[2,3-d]pyrimidin-7-ones and...

Details Pyrrolyl substituted pyrido[2,3-d]pyrimidin-7-ones and... Pyrrolyl substituted pyrido[2,3-d]pyrimidin-7-ones and...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2563669

The present invention provides pyrimidines of Formula (I): wherein R2, R4, R5, R6, R8 and J have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (I).

L'invention se rapporte à des pyrimidines de la formule (1): dans laquelle R?2¿, R?4¿, R?5¿, R?6¿, R?8¿ et J possèdent une quelconque valeur parmi les valeurs définies dans la spécification, et à des sels pharmaceutiquement acceptables de ces dernières, qui sont utilisés comme agents dans le traitement de maladies, y compris de maladies inflammatoires, de maladies cardiovasculaires et de cancers. L'invention concerne également des compositions pharmaceutiques renfermant un ou plusieurs composés de la formule (1).

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