Pyrrolylbenzodiazepinones

Details Pyrrolylbenzodiazepinones Pyrrolylbenzodiazepinones

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2086368

RAN 4430/50 Abstract The present invention relates to compounds of the formula Image I wherein R is methyl, fluorine or bromine, and pharmaceutically acceptable salts thereof. Utilizable as therapeutically active agents especially for the treatment of retroviral infections, particularly HIV infections, they can be prepared in a manner known per se by a process which comprises reacting 2-bromo-2'-(1H-pyrrol-2-yl- carbonyl)acetanilide, correspondingly substituted by R in the 4'-position, with ammonia and cyclizing the obtained 2-aminoacetanilide with pivalic acid.

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