Quantification and generation of immune suppressive exosomes

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/02 (2006.01) A61K 35/14 (2006.01) A61K 35/18 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2453198

Methods of identifying and quantifying immune suppressive factors in biological fluids of cancer patients comprising purification and assessment of small (60-250nm) microvesicles are disclosed. Said microvesicles can serve alone, or in combination with other immunological assays as a prognastic indicator for a cancer patient, or alternatively as a determinant for various immunological and non-immunological therapeutic interventions. Methods of generating immune suppressive exosomes are also described.

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