Quantitation by serial combinatorial dilution

Details Quantitation by serial combinatorial dilution Quantitation by serial combinatorial dilution

C - Chemistry, Metallurgy

12

Q

C12Q 1/06 (2006.01) C12Q 1/68 (2006.01) G01N 1/38 (2006.01) G01N 27/447 (2006.01) G01N 27/62 (2006.01) G01N 30/02 (2006.01) G01N 30/72 (2006.01) G01N 33/48 (2006.01) G01N 33/483 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) G01N 35/00 (2006.01)

Patent

CA 2490301

The invention provides a method for the quantification of a biomolecule in a complex mixture of biomolecules which comprises a fractionation of the mixture of biomolecules providing at least two fractions with at least one distinct component each. These fractions are then subjected to serial combinatorial dilution. Subsequently, the biomolecule is detected and identified in the fractions by a method providing a sensitivity threshold and identify information. The quantity of the biomolecule is determined by summarizing the number of identifications of the biomolecule in each fraction on each dilution level in consideration of the respective dilution factor. For purpose of normalization this sum may be divided by the total number of identifications of all biomolecules in all fractions on all dilution levels.

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