Quantitation of p97 to diagnose and monitor alzheimer's disease

G - Physics – 01 – N

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G01N 33/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2230372

A method of diagnosing Alzheimer's Disease by quantitating p97 in a sample of body fluid from a human individual comprising the steps of: a) obtaining a sample of body fluid from an individual suspected of having Alzheimer's Disease, thereby obtaining a test sample; b) determining the amount of p97 in the test sample; and c) comparing the amount of p97 in the test sample with an amount of p97 in control samples, wherein the presence of an amount of p97 in the test sample which is elevated as compared with the amount of p97 in the control samples is indicative of the potential for Alzheimer's Disease.

Un procédé de diagnostic de la maladie d'Alzheimer par quantification de p97 dans un échantillon de liquide biologique prélevé sur un individu humain comprend les étapes consistant: a) à prélever un échantillon de liquide biologique sur un individu dont on pense qu'il est atteint de la maladie d'Alzheimer, à obtenir ainsi un échantillon de test; b) à déterminer la quantité de p97 dans l'échantillon de test; c) à comparer la quantité de p97 dans l'échantillon de test avec une quantité de p97 dans des échantillons témoins, la présence d'une quantité de p97 dans l'échantillon de test élevée comparée à la quantité de p97 dans les échantillons témoins indiquant une maladie d'Alzheimer potentielle.

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