Quantitative analysis of a turbid pharmaceutical sample by...

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G01N 21/17 (2006.01) G01N 21/35 (2006.01) G01N 21/62 (2006.01)

Patent

CA 2442275

The present invention relates to apparatuses for use in performing a quantitative analysis of a turbid pharmaceutical sample, e.g. a tablet, a capsule or a similar sample forming a pharmaceutical dose. A pharmaceutical, turbid sample (24, 57, 67) is irradiated with an excitation beam (20, 53, 64) of radiation, e.g. near infrared radiation. The intensity of emitted radiation (30) from the sample (24, 57, 67) is detected as function of both the wavelength of the emitted radiation and the photon propagation time through said sample (24, 57, 67). Optionally, the intensity of the emitted radiation (30) from the sample (24, 57, 67) is also detected in a spatially resolved manner.

L'invention concerne des appareils destinés à être utilisés pour effectuer une analyse quantitative d'un échantillon pharmaceutique trouble, par exemple, comprimé, capsule ou échantillon analogue, formant une dose pharmaceutique. Un échantillon pharmaceutique trouble (24, 57, 67) est irradié par un faisceau d'excitation (20, 53, 64) d'un rayonnement, par exemple, proche du rayonnement infrarouge. L'intensité du rayonnement émis (30) par l'échantillon (24, 57, 67) est détectée en fonction à la fois de la longueur d'onde du rayonnement émis et du temps de propagation des photons à travers ledit échantillon (24, 57, 67). Selon une variante, l'intensité du rayonnement émis (30) par l'échantillon (24, 57, 67) est également détectée par résolution spatiale.

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