C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2441314
The invention relates to the application of the direct correlation between the overexpression or the functional molecular modification of human homologs of the sgk family and hypertension for quantitative diagnosis of a particular form of genetically determined hypertension. In particular the invention relates to the detection of a direct link between two different polymorphisms of individual nucleotides in the hsgk1 gene and the genetically determined predisposition to hypertension. The invention further relates to the provision of a diagnostic kit containing antibodies or polynucleotides for detecting the diagnostic targets hsgk1, hsgk2 and hsgk3.
La présente invention concerne l'utilisation de la corrélation directe entre la surexpression ou la modification moléculaire fonctionnelle d'homologues humains de la famille sgk et l'hypertonie permettant le diagnostic quantitatif d'une forme donnée de l'hypertonie d'origine génétique. L'invention concerne notamment la mise en évidence d'une relation directe entre deux polymorphismes différents de nucléotides individuels dans le gène hsgk1 et de la prédisposition génétique à l'hypertonie. L'invention a également pour objet la préparation d'un kit de diagnostic contenant des anticorps ou des polynucléotides afin de mettre en évidence les cibles diagnostiques hsgk1, hsgk2 et hsgk3.
Busjahn Andreas
Lang Florian
Luft Friedrich C.
Fetherstonhaugh & Co.
Lang Florian
LandOfFree
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