G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 15/14 (2006.01) G01N 21/64 (2006.01) G01N 1/22 (2006.01) G01N 15/00 (2006.01) G01N 35/00 (2006.01)
Patent
CA 2424039
The present invention thus relates to marker components, fluorescent probes, oligonucleotides, hybridization assays, and binding assays such as immunoassays, DNA assays and receptor assays using such products and methods for making such products. According to the present invention, delectably labeled marker components are provided thus comprise a fluorophore moiety coupled to two or more small solubilizing axial ligands, which preferably reduce or remove the problems of solvent sensibility and non-specific binding.
La présente invention concerne des composants marqueurs, des sondes fluorescentes, des oligonucléotides, des essais d'hybridation et des analyses de liaison, notamment des immuno-essais, des analyses d'ADN et des analyses de récepteurs utilisant de tels produits, ainsi que des techniques destinées à fabriquer ces produits. La présente invention se rapporte également à des composants marqueurs marqués de manière détectable et comprenant une entité fluorophore couplée à deux ou plusieurs petits ligands axiaux solubilisants. De préférence, ces ligands permettent de réduire ou d'éliminer les problèmes de sensibilité au solvant et de liaison non spécifique.
Botz Eduard J.
Lin Tsue-Ming
Newton Kenneth R.
Rana Victoriano F.
Hyperion Inc.
Smart & Biggar
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