C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2493919
The present application relates to novel composite primers which make it possible to amplify in multiplex at a quantitative level of precision, and to the application of these composite primers for detecting gnomic rearrangements in general,and cryptic chromosomal rearrangements in particular. These composite primers contain a tag the sequence of which is absent from or poorly represented in the genome analyzed, and which exhibits a very low propensity to form stable pairings. The composite primers, which contain them, make it possible to carry out multiplex amplifications with quantitative precision on the scale of a genome such as the human genome.
La présente invention concerne de nouvelles amorces composites permettant une amplification en multiplex à un niveau de précision quantitative, ainsi que l'application de ces amorces composites dans la détection de réarrangements génomiques en général, et de réarrangements chromosomiques cryptiques en particulier. Lesdites amorces composites contiennent une étiquette dont la séquence est absente ou peu représentée dans le génome analysé, et présentant une très faible propension à former des appariements stables. Les amorces composites contenant ladite étiquette permettent de réaliser des amplifications en multiplex avec une précision quantitative à l'échelle génomique, par ex. dans le génome humain.
Frebourg Thiery
Raux Gregory
Tosi Mario
Inserm
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Universite de Rouen
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