Quantitative rt-pcr to ac133 to diagnose cancer and monitor...

C - Chemistry – Metallurgy – 12 – P

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C12P 19/34 (2006.01) C07H 21/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2496003

The present invention involves the use of quantitative RT-PCR to identify AC133 as a marker. AC133 is prevalent on endothelial progenitor cells (EPCs), which are important cells in angiogenesis. Therefore, the invention is applied to ascertain the quantity of EPCs in a subject, and to diagnose and monitor angiogenesis, for example, in injured tissues and in cancer development and progression.

L'invention concerne l'utilisation de RT-PCR quantitative pour identifier AC133 comme marqueur. AC133 est courant sur les cellules souches endothéliales (EPC), qui jouent un rôle important dans l'angiogénèse. La présente invention concerne donc la détermination de la quantité d'EPC chez un sujet, ainsi que le diagnostic et la surveillance de l'angiogénèse, par exemple, dans des tissus blessés et dans le développement d'un cancer.

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