Quantitative testing for vitamin b in12 xx

Details Quantitative testing for vitamin b in12 xx Quantitative testing for vitamin b in12 xx

G - Physics

01

N

150/11, 150/3

G01N 33/82 (2006.01) G01N 33/56 (1980.01)

Patent

CA 1140439

ABSTRACT The vitamin B12 (cobalamin) level of human blood and mammalian tissue is routinely assayed utilizing radioisotope dilution assay (RIDA) techniques. The presence of vitamin "B12 analogues" in such samples, which analogues are erron- eously assayed as true vitamin B12 utilizing prior art RIDA techniques, has been determined. Such errors are due to the fact that birding proteins commonly used in prior art RIDA techniques normally include proteins which bind both true vitamin B12 and previously unrecognized vitamin B12 analogues. The errors caused by the B12 analogues are avoided by using a composition for binding vitamin B12 which is substantially free of substances which bind vitamin B12 analogues. Moreover, by using both types of binders in separate assays, the amount of analogue present may be arrived at by taking the difference of the assays.

324919

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