Quarternary derivatives of noroxymorphone which relieve...

Details Quarternary derivatives of noroxymorphone which relieve... Quarternary derivatives of noroxymorphone which relieve...

A - Human Necessities

61

K

167/245

A61K 31/485 (2006.01) C07D 489/08 (2006.01)

Patent

CA 1315689

- 9 - QUATERNARY DERIVATIVES OF NOROXYMORPHONE WHICH RELIEVE NAUSEA AND EMESIS ABSTRACT OF THE DISCLOSURE Quaternary derivatives of noroxymorphone are used to prevent or relieve nausea and emesis associated with the use of narcotic analgesics without interfering with the analgesic activity of the drugs. A particularly preferred compound is methylnaltrexone. The compound is administered in a concentration between 0.05 mg/kg and 1.0 mg/kg prior to or concurrently with the administration of the narcotic analgesic.

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