Quaternary 3 -amido, n-methylpyridinium salts as anti...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/82 (2006.01) A61K 31/435 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2629913

A novel group of anti-inflammatory compounds are salts composed of the anion of a nonsteroidal anti-inflammatory acid drug (NSAID) and the cation N(l)- methylnicotinamide, which both anion and cation moieties alone exhibit anti- inflammatory activity, and which in this combination have advantages over the individual compounds and in comparison to commercial anti-inflammatory products. The compounds are produced in analogy to processes known in the art. They are used for the preparation of new pharmaceutical formulations with anti- inflammatory and analgesic activity. The new pharmaceutical formulations exhibit several advantageous properties over preparations of prior art.

La présente invention concerne un nouveau groupe de composés anti-inflammatoires. Lesdits composés sont des sels composés de l'anion d'un médicament acide anti-inflammatoire non stéroïdien (AINS) et du cation N(l)-méthylnicotinamide. Les entités d'anion et de cation présentent chacune une activité anti-inflammatoire et réunies au sein de cette association, elles présentent des avantages sur les composés individuels ainsi que par rapport aux anti-inflammatoires vendus dans le commerce. Lesdits composés sont produits selon les procédés connus de la technique. Ils sont utilisés pour la préparation de nouvelles formulations pharmaceutiques dotées d'une activité anti-inflammatoire et analgésique. Ces nouvelles formulations pharmaceutiques présentent plusieurs propriétés avantageuses par rapport aux préparations selon la technique antérieure.

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