Quaternary alkyl ammonium bacterial efflux pump inhibitors...

Details Quaternary alkyl ammonium bacterial efflux pump inhibitors... Quaternary alkyl ammonium bacterial efflux pump inhibitors...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/47 (2006.01) A61K 38/05 (2006.01) A61P 31/04 (2006.01) C07D 215/38 (2006.01)

Patent

CA 2686997

Disclosed are compounds having at least one quaternary alkyl ammonium functionality. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti -bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti -bacterial agents through an efflux pump mechanism.

L'invention concerne des composés présentant au moins une fonctionnalité alkylammonium quaternaire. Ces composés sont des inhibiteurs de pompes à efflux bactériennes et sont utilisés en combinaison avec un agent antibactérien pour traiter ou prévenir des infections bactériennes. Ces combinaisons peuvent être efficaces contre les infections bactériennes ayant développé une résistance aux agents antibactériens par mise en oeuvre d'un mécanisme de pompe à efflux.

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