Quaternary amine containing ether or ester lipid derivatives...

Details Quaternary amine containing ether or ester lipid derivatives... Quaternary amine containing ether or ester lipid derivatives...

C - Chemistry, Metallurgy

07

C

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C07C 217/28 (2006.01) C07C 217/08 (2006.01) C07C 217/30 (2006.01) C07C 219/06 (2006.01) C07C 323/12 (2006.01) C07C 323/25 (2006.01) C07D 213/20 (2006.01) C07D 277/24 (2006.01) C07D 295/037 (2006.01) C07D 317/28 (2006.01) C07D 327/04 (2006.01) C07D 339/06 (2006.01) C07D 409/06 (2006.01) C07D 411/06 (2006.01) C07D 521/00 (2006.01) C07F 9/10 (2006.01)

Patent

CA 2001401

-69- QUATERNARY AMINE CONTAINING ETHER OR ESTER LIPID DERIVATIVES AND THERAPEUTIC COMPOSITIONS Abstract of the Disclosure Quaternary amine-containing ether lipid analogs of the formula R1-X-R2-N+(R3)(R4)(R5) Z- are disclosed. R1 represents a hydrophobic group and R2 represents the backbone of the molecule, with the quaternary amine being linked directly to the backbone. Pharmaceutical compositions including these compounds and methods of combating tumors with these compounds are disclosed. Also disclosed is a method of combating viral infections with both these compounds and ET-18-OMe and its analogs.

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