Quaternary ammonium compound, process for producing the...

C - Chemistry – Metallurgy – 07 – C

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C07C 217/18 (2006.01) A61K 31/205 (2006.01) A61P 9/10 (2006.01) C07C 213/00 (2006.01) C07C 309/42 (2006.01)

Patent

CA 2561601

A quaternary ammonium compound represented by the general formula (I) or (I'): (I) or (I') wherein A represents C<sub>1-4</sub> linear alkyl, C<sub>2-4</sub> branched alkyl, hydroxylated C<sub>1-4</sub> linear alkyl, or hydroxylated C<sub>2-4</sub> branched alkyl; R<sub>1</sub> to R<sub>3</sub> are the same or different and each represents linear or branched C<sub>1-12</sub> alkyl; one of R<sub>4</sub> to R<sub>8</sub> represents CO<sub>2</sub><sup>-</sup> or SO<sub>3</sub><sup>-</sup>, at most three of the remaining ones of R<sub>4</sub> to R<sub>8</sub> each represents a group selected from the group consisting of hydroxy and C<sub>1-4</sub> alkoxy, and the remainder of R<sub>4</sub> to R<sub>8</sub> represents hydrogen; one of R'<sub>4</sub> to R'<sub>8</sub> represents CO<sub>2</sub>H or SO<sub>3</sub>H, at most three of the remaining ones of R'<sub>4</sub> to R'<sub>8</sub> each represents a group selected from the group consisting of protected hydroxy and C<sub>1-4</sub> alkoxy, and the remainder of R'<sub>4</sub> to R'<sub>8</sub> represents hydrogen; and X<sup>-</sup> represents an anion capable of forming a salt with the quaternary ammonium group.

Un composé d~ammonium quaternaire représenté par la formule générale (I) ou (I') : (I) ou (I') où A représente un alkyle linéaire en C<sub>1</sub> à C<sub>4</sub>, un alkyle ramifié en C<sub>2</sub> à C<sub>4</sub>, un alkyle linéaire en C<sub>1</sub> à C<sub>4 </sub>hydroxylé, ou un alkyle ramifié en C<sub>2</sub> à C<sub>4 </sub>hydroxylé, R<sub>1</sub> à R<sub>3</sub> sont les mêmes ou sont différents et chacun représente un alkyle linéaire ou ramifié enC<sub>1</sub> à C<sub>12</sub>, un parmi R<sub>4</sub> à R<sub>8</sub> représente CO<sub>2</sub><sup>- </sup>ou SO<sub>3</sub><sup>-</sup>, tout au plus trois des restants parmi R<sub>4</sub> à R<sub>8</sub> représentent chacun un groupe choisi parmi le groupe comprenant un hydroxy et un alcoxy en C<sub>1</sub> à C<sub>4</sub>, et les restants parmi R<sub>4</sub> à R<sub>8</sub> représentent l~hydrogène, un parmi R'<sub>4</sub> à R'<sub>8</sub> représente CO<sub>2</sub>H ou SO<sub>3</sub>H, tout au plus trois des restants parmi R'<sub>4</sub> à R'<sub>8 </sub>représentent chacun un groupe choisi parmi le groupe comprenant un hydroxy et un alcoxy en C<sub>1</sub> à C<sub>4 </sub>protégés, et les restants parmi R'<sub>4</sub> à R'<sub>8</sub> représentent l~hydrogène ; et X représente un anion susceptible de former un sel avec le groupe ammonium quaternaire.

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