C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/06 (2006.01) A61K 31/343 (2006.01) A61K 31/4025 (2006.01) A61P 11/06 (2006.01)
Patent
CA 2502833
The invention features quaternary ammonium compounds of formula (I), and any stereoisomers thereof, wherein R1 is selected from C1-C6 alkyl, -CH2-(C1-C4 alkenyl), and -CH2-(C1-C6 alkynyl), each of which is optionally substituted with a group selected from phenyl, C1-C4 alkoxy, and hydroxyl; and X represents an anion of a pharmaceutically acceptable acid, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious rhinitis.
L'invention concerne des composés d'ammonium quaternaire de formule (I), et de leurs stéréosimères, dans laquelle R¿1? est sélectionné parmi alkyle C¿1?-C¿6?, -CH¿2?-(alcényle C¿1?-C¿4?), et, -CH¿2?-(alkynyle C¿1?-C¿6?), chacun étant éventuellement substitué par un groupe sélectionné parmi phényle, alcoxy C¿1?-C¿4?, et hydroxyle ; et X représente un anion d'un acide pharmaceutiquement acceptable. L'invention concerne également leur utilisation dans le traitement de l'asthme, de troubles pulmonaires obstructifs chroniques, de la rhinite allergique, et de la rhinite infectieuse.
Heath Timothy Gordon
Meglasson Martin Durham
Richards Ivan Michael
Pharmacia & Upjohn Company Llc
Smart & Biggar
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