C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 205/04 (2006.01) A61K 31/397 (2006.01) A61K 31/4468 (2006.01) A61K 31/4525 (2006.01) A61K 31/453 (2006.01) A61K 31/4535 (2006.01) A61K 31/454 (2006.01) A61P 11/06 (2006.01) C07D 211/26 (2006.01) C07D 211/58 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2682032
The invention provides compounds of the formula: (I) in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
La présente invention concerne des composés de formule (I) sous forme de sel ou zwitterionique ou un sel pharmaceutiquement acceptable de ceux-ci, dans laquelle R1-6, a, Z and Q sont tels que définis dans la description. Ces composés sont des antagonistes des récepteurs muscariniques. L'invention concerne également des compositions pharmaceutiques contenant de tels composés, des procédés de préparation de tels composés et des procédés d'utilisation de tels composés, par exemple, pour traiter des troubles pulmonaires tels que la bronchopneumopathie chronique obstructive et l'asthme.
Husfeld Craig
Ji Yu-Hua
Lee Rick
Li Li
Mu Yongqi
Theravance Inc.
Torys Llp
LandOfFree
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