C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/08 (2006.01) A61K 31/40 (2006.01) A61P 11/00 (2006.01) C07D 207/09 (2006.01)
Patent
CA 2675942
The invention provides compounds of formula (I) in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R 1-6, a-e and Q are as defined in the specification,. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
L'invention concerne des composés de formule (I) sous forme saline ou zwitterionique ou un sel pharmaceutiquement acceptable, où R1-6, a à e et Q sont tels que définis dans la description. Ces composés sont des antagonistes de récepteur muscarinique. L'invention concerne également des compositions pharmaceutiques contenant de tels composés, des procédés pour préparer de tels composés, et des procédés d'utilisation de tels composés, par exemple pour traiter des troubles pulmonaires tels qu'une bronchopneumopathie obstructive chronique et l'asthme.
Husfeld Craig
Ji Yu-Hua
Lange Christopher
Lee Rick
Mu Yongqi
Theravance Inc.
Torys Llp
LandOfFree
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