Quaternary ammonium salts and their use

Details Quaternary ammonium salts and their use Quaternary ammonium salts and their use

C - Chemistry, Metallurgy

07

D

C07D 337/08 (2006.01) A61K 31/335 (2006.01) A61K 31/351 (2006.01) A61K 31/452 (2006.01) A61K 31/4523 (2006.01) A61K 31/5377 (2006.01) A61K 31/665 (2006.01) A61K 31/67 (2006.01) A61P 31/18 (2006.01) C07C 233/62 (2006.01) C07D 309/14 (2006.01) C07D 313/08 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2337307

This invention is to provide a compound for antagonizing CCR5, said compound being represented by formula (I), wherein R1 is an optionally substituted phenyl or an optionally substituted thienyl; Y is -CH2-, -S- or -O-; and R2, R3 and R4 are independently an optionally substituted aliphatic hydrocarbon group or an optionally substituted alicyclic heterocyclic ring group, and being effective for the prevention and treatment of infectious disease of HIV.

L'invention concerne un composé permettant de contrarier CCR5, ce composé étant représenté par la formule (I), dans laquelle R?1¿ représente un phényle éventuellement substitué ou un thiényle éventuellement substitué ; Y représente -CH¿2?-, -S-, ou -O- ; et R?2¿, R?3¿, et R?4¿ représentent indépendamment un groupe aliphatique hydrocarboné éventuellement substitué ou un groupe hétérocyclique alicyclique éventuellement substitué. Le composé de cette invention permet de prévenir et de traiter efficacement les infections à VIH.

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