Quaternary ammonium salts of dantrolene and clodanolene

Details Quaternary ammonium salts of dantrolene and clodanolene Quaternary ammonium salts of dantrolene and clodanolene

C - Chemistry, Metallurgy

07

D

260/290.2, 260/3

C07D 405/12 (2006.01) C07D 405/14 (2006.01)

Patent

CA 1116602

ABSTRACT OF THE DISCLOSURE Certain quaternary ammonium salts of dantrolene and clodanolene of the formula: Image wherein X is 4-nitro or 3,4-dichloro; .theta.NR4 is N-methylpyridinium, 3,7-diamino-2,8-dimethyl-5-phenylphenazinium, 2,3-dimethyl-1- phenyl-4-trimethylammonium -3-pyrazoline-5-one, 1,3-dimethylimi- dazolium, choline, or 2-methyl-2-trimethylammonium-1-propanol; and n is 0, 0.75 or 1.5, are effective skeletal muscle relaxants.

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