C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 265/30 (2006.01) C07C 211/62 (2006.01) C07C 233/40 (2006.01) C07C 233/44 (2006.01) C07C 233/51 (2006.01) C07C 235/78 (2006.01) C07C 237/20 (2006.01) C07C 237/22 (2006.01) C07D 211/08 (2006.01) C07D 295/13 (2006.01)
Patent
CA 2458035
(R)-Enantiomers of quaternary ammonium salts of general formula (I) are described: (I) where R, R1, R2, R3, X and Z are as defined in the description. The process for their preparation and pharmaceutical preparations thereof are also described. The quaternary salts of the invention are useful in the inhibition of chemotaxis of neutrophils and monocytes induced by the fraction C5a of the complement and are used in the treatment of psoriasis, pemphigus and pemphigoid, rheumatoid arthritis, intestinal chronic inflammatory pathologies including ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, cystic fibrosis, chronic obstructive pulmonary disease and glomerulonephritis. The compounds of the invention are advantageously used in the prevention and the treatment of injury caused by ischemia and reperfusion.
L'invention porte: sur des (R)-Enantiomères de sels d'ammonium quaternaire de formule générale (I) dans laquelle: R, R¿1?, R¿2?, R¿3?, X et Z sont tels que définis dans la description; et sur le procédé de préparation. Lesdits sels qui inhibent la chimiotaxie des neutrophiles et des monocytes dus à la fraction Ca du complément servent au traitement du psoriasis, du pemphigus et du pemphigoïde, de l'arthrite rhumatoïde, des pathologie intestinales inflammatoires chroniques dont la rectocolite hémorragique, l'infection aiguë des voies respiratoires, la fibrose idiopathique, la fibrose kystique, la broncho-pneumopathie chronique obstructive, et la glomérulonéphrite. Les composés de l'invention seront avantageusement utilisés pour la prévention et le traitement de lésions dues à l'ischémie et à la reperfusion.
Allegretti Marcello
Bertini Riccardo
Bizzarri Cinzia
Cesta Maria Candida
Dompe Pha.r.ma S.p.a.
Dompe S.p.a.
Kirby Eades Gale Baker
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