Quaternary basic amides, method of preparing them and...

Details Quaternary basic amides, method of preparing them and... Quaternary basic amides, method of preparing them and...

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/55 (2006.01) C07D 471/02 (2006.01) C07D 487/02 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2107432

The invention relates to quaternary basic amides of the formula (see formula I) in which - Ar is an optionally substituted mono-, di- or tri-cyclic aromatic or heteroaromatic group - T is a direct bond, a hydroxymethylene group, an alkoxymethylene group in which the alkoxy group is C1-C4, or a C1-C5-alkylene group; - Ar' is an unsubstituted or mono- or poly-substituted phenyl, a thienyl, a benzothienyl, a naphthyl or an indolyl; - R is hydrogen or a C1-C4-alkyl, or a C1-C4-.omega.-alkoxy(C2-C4)alkyl, or a C2-C4-.omega.-alkanoyloxy (C1-C4)alkyl;. - Q is hydrogen: - or else Q and R together form a 1,2-ethylene, 1,3-propylene or 1,4-butylene group: - Am+ is the radical (see formula II) in which X1, X2 and X3, together with the nitrogen atom to which they are bonded, form an azabicyclic or azatricyclic system optionally substituted by a phenyl group; and - A- is a pharmaceutically acceptable anion. These compounds are useful for the preparation of drugs intended for the treatment of pathological conditions involving the tachykinin system.

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