Quaternary cytofectins

Details Quaternary cytofectins Quaternary cytofectins

C - Chemistry, Metallurgy

07

C

C07C 217/08 (2006.01) A61K 31/70 (2006.01) A61K 47/18 (2006.01) A61K 48/00 (2006.01) C07C 237/06 (2006.01) C07C 271/22 (2006.01) C07C 275/14 (2006.01) C07C 279/14 (2006.01) C07C 323/25 (2006.01) C07C 391/00 (2006.01) C07H 21/00 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2251169

Cationic lipids, having a derivatized quaternary ammonium head group, that provide improved cell targeting ability and enhanced transfective efficacy for the delivery of molecules into cells. The lipids comprise a linker having funtional groups that provide sites for further attachment of drugs, cell receptor ligands or other bioactive agents.

Cette invention concerne des lipides cationiques possédant un groupe tête d'ammonium quaternaire dérivé qui améliorent la capacité de ciblage de cellules et l'efficacité transgénique pour apporter des molécules dans des cellules. Les lipides comprennent une séquence de liaison comportant des groupes fonctionnels qui servent de sites pour la fixation d'autres substances thérapeutiques, d'autres ligands de récepteur cellulaire ou d'autres agents bioactifs.

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