C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/547 (2006.01) A61K 31/66 (2006.01) C07F 9/38 (2006.01) C07F 9/572 (2006.01) C07F 9/576 (2006.01) C07F 9/58 (2006.01) C07F 9/59 (2006.01) C07F 9/6506 (2006.01)
Patent
CA 2136825
The present invention relates to quaternary nitrogen-containing phosphonate compounds, and the pharmaceutically-acceptable salts and esters thereof and having general structure (I). The present invention further relates to pharmaceutical compositions containing a safe and effective amount of a compound of the present invention, and pharmaceutically acceptable excipients. Finally, the present invention relates to methods for treating or preventing pathological conditions characterized by abnormal calcium and phosphate metabolism such as osteroporosis, rheumatoid arthritis, and osteoarthritis in humans or other mammals and to methods for treating or preventing dental calculus, plaque and gingivitis. This method comprises administering to a human or other mammal in need of such treatment a safe and effective amount of a compound or composition of the present invention.
La présente invention concerne des composés de type phosphonate contenant de l'azote quaternaire, et les sels et esters pharmaceutiquement acceptables de ces derniers et ayant la structure générale (I). La présente invention concerne également des compositions pharmaceutiques contenant une quantité sûre et efficace d'un composé de la présente invention et des excipients pharmaceutiquement acceptables. Enfin, la présente invention concerne des méthodes pour traiter ou prévenir les manifestations pathologiques caractérisées par un métabolisme anormal du calcium et du phosphate comme l'ostéoporose, la polyarthrite rhumatoïde et l'ostéoarthrite chez les humains ou d'autres mammifères ainsi que des méthodes pour traiter ou prévenir le tartre dentaire, la plaque et la gingivite. Cette méthode comprend l'administration à la personne ou au mammifère qui a besoin de traitement d'une quantité sûre et efficace d'un composé ou de la composition de la présente invention.
Ebetino Frank H.
Francis Marion D.
Janusz John M.
Kaas Susan M.
Nelson Dennis G. A.
Kirby Eades Gale Baker
Procter & Gamble Pharmaceuticals Inc.
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