Quaternised ammonium cyclodextrin compounds for use as...

Details Quaternised ammonium cyclodextrin compounds for use as... Quaternised ammonium cyclodextrin compounds for use as...

A - Human Necessities

61

K

A61K 31/724 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2487332

Use of a compound of formula (I), wherein the symbol (a) represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula (II) per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl and cycloheteryl; Xm- is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.

L'invention concerne l'utilisation d'un composé de formule (I) dans la préparation d'un médicament anti-infectieux comme conservateur et substance favorisant la pénétration, formule (I) dans laquelle le symbole (a) désigne un résidu de valence n dérivé d'un composé de cyclodextrine présentant des groupes hydroxyles desquels n est retiré ; n est un nombre supérieur à 0 et désigne le nombre moyen de substituants de formule (II) par molécule dudit composé ; h est égal à 0 ou à 1 ; R¿1? est un groupe divalent sélectionné parmi alkylène, hydroxyalkylène, alkylène halogéné, aralkylène monocyclique, cycloalkylène et phénylène ; R¿2?, R¿3? et R¿4? représentent chacun indépendamment de l'autre un groupe sélectionné parmi alkyle, cycloalkyle, aryle, aralkyle et cyclohétéryle ; X?m-¿ est un anion m fois chargé négativement ; m est un nombre entier égal ou supérieur à 1 et k représente n/m.

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