Quenolines and related analogs as sirtuin modulators

Details Quenolines and related analogs as sirtuin modulators Quenolines and related analogs as sirtuin modulators

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/395 (2006.01) A61K 31/4709 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) C07D 215/16 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2723135

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

L'invention concerne de nouveaux composés de modulation de sirtuine et des procédés d'utilisation de ceux-ci. Les composés de modulation de sirtuine peuvent être utilisés pour augmenter la durée de vie d'une cellule, et traiter et/ou empêcher une grande diversité de maladies et de troubles y compris, par exemple, des maladies ou des troubles relatifs au vieillissement ou au stress, des diabètes, l'obésité, des maladies neurodégénératives, une maladie cardio-vasculaire, des troubles de la coagulation du sang, une inflammation, un cancer, et/ou une congestion ainsi que des maladies ou des troubles qui bénéficieraient d'une activité mitochondriale accrue. Des compositions sont également fournies comprenant un composé de modulation de sirtuine en association avec un autre agent thérapeutique.

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