G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01)
Patent
CA 2540841
The invention relates to method for the diagnosis of Alzheimer's disease or the early stages thereof or a predisposition to said disease. Said method is based on quantitative determination of a mitogenically expressible surface marker, in particular CD69, and peripherally accessible cells, e.g. skin cells or lymphocytes, (a) prior to and (b) after mitogenic stimulation. A specific stimulation index a:b is an indication of Alzheimer's disease or early stages thereof or of a predisposition to said disease. The invention also relates to kits which are suitable for carrying out the inventive method of diagnosis.
L'invention concerne un procédé permettant de diagnostiquer la maladie d'Alzheimer, un stade précoce de cette maladie ou une prédisposition à cette maladie. Ce procédé comporte la détermination quantitative de marqueurs de surface exprimables par voie mitogène, de préférence de CD69, de cellules d'accès périphérique, par exemple, de cellules cutanées ou de lymphocytes (a) avant et (b) après une stimulation mitogène. Un certain indice de stimulation a:b est un signe de la maladie d'Alzheimer, d'un stade précoce de cette maladie ou d'une prédisposition à cette maladie. L'invention concerne également des trousses permettant de mettre en oeuvre ce procédé de diagnostic.
Arendt Thomas
Stieler Jens
Smart & Biggar
Universitat Leipzig
LandOfFree
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