C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/48 (2006.01) A61K 38/43 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C12N 5/02 (2006.01) C12N 9/50 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2383910
Disclosed herein are the cDNA and polypeptide sequences of a novel cytoplasmic post-prolyl dipeptidase, QPP. QPP is expressed in T-cells and in neurons, and functions to protect quiescent cells from apoptotic death. Therefore, QPP can be used as a therapeutic to inhibit apoptotic cell death and as a target in screening for compounds that modulate cell death.
Cette invention a trait à de l'ADN complémentaire ainsi qu'à des séquences polypeptidiques d'une nouvelle dipeptidase post-prolyl cytoplasmique, QPP. Cette QPP est exprimée dans des lymphocytes T et des neurones et elle agit pour protéger de l'apoptose des cellules quiescentes. Il est ainsi possible d'utiliser la QPP comme agent thérapeutique inhibant la mort cellulaire ainsi que comme cible dans des criblages de composés modulant la mort cellulaire.
Huber Brigitte T.
Underwood Robert H.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Tufts University
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