Quiescent cell populations for nuclear transfer

Details Quiescent cell populations for nuclear transfer Quiescent cell populations for nuclear transfer

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A01K 67/027 (2006.01) A61D 19/04 (2006.01) A61K 35/54 (2006.01) C12N 5/16 (2006.01) C12N 15/06 (2006.01) C12N 15/87 (2006.01) C12N 15/89 (2006.01)

Patent

CA 2229568

A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state. Nuclear transfer may take place by cell fusion. The reconstituted embryo may then give rise to one or more animals. The invention is useful in the production of transgenic animals as well as non- transgenics of high genetic merit.

Procédé de reconstitution d'un embryon animal consistant à transférer le noyau depuis une cellule donneuse quiescente vers une cellule réceptrice adaptée. La cellule donneuse est quiescente, en ce qu'elle est amenée à sortir du cycle de croissance et de division à G1 et à demeurer à l'état G0. Un transfert nucléaire peut avoir lieu par fusion de cellules. L'embryon reconstitué peut alors donner naissance à un ou plusieurs animaux. L'invention est utile à la production d'animaux transgéniques ou non transgéniques de grande qualité génétique.

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