Quinazol in -2-ones

Details Quinazol in -2-ones Quinazol in -2-ones

A - Human Necessities

61

K

167/218

A61K 31/505 (2006.01)

Patent

CA 1125170

ABSTRACT OF THE DISCLOSURE Compounds of the formula Image wherein R1 is hydrogen; alkyl having 4-20 carbons; cyclo- alkyl, heterocycloalkyl; halo; COO loweralkyl; CN; COOH; CH2OH; CH (O-loweralkyl)2 or nitro; and X and Y are each hydrogen; halo; nitro; loweralkyl; loweralkoxy; aryl; arylalkyloxy; hydroxy; acyloxy; aryloxy; amino; loweralkyl- amino; diloweralkylamino; amido; loweralkylamido; diloweralkyl- amido; cyano; COOH; COO loweralkyl; CHO; CH2OH; CH2O acyl; or CH2O aryl. The compounds find use in the treatment of hypertension and bradycardia and as a cardiotonic agent.

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