Quinazolin-4-one derivatives

Details Quinazolin-4-one derivatives Quinazolin-4-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/517 (2006.01) A61P 11/06 (2006.01) A61P 15/00 (2006.01) A61P 25/04 (2006.01) A61P 25/20 (2006.01) A61P 25/28 (2006.01) A61P 27/00 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 239/92 (2006.01)

Patent

CA 2503674

Drugs having inhibitory activity against hematopoietic prostaglandin D2 synthase, containing as the active ingredient compounds represented by the general formula (I) or salts thereof: (I) wherein X is -N=C(R5)- or -NH-CH(R5)- ; R1, R2, R3, and R4 are each hydrogen, halogeno, C1-6 alkyl, or hydroxyl; R5 is C1-6 alkyl or C6-10 aryl; and R is amino.

La présente invention concerne des produits pharmaceutiques ayant une activité d'inhibition sur la synthase de prostaglandine D2 hématopoïétique, contenant comme principe actif des composés de formule générale (I) ou des sels de ceux-ci. Dans la formule (I), X est -N=C(R?5¿)- ou -NH-CH(R?5¿)-; R?1¿, R?2¿, R?3¿ et R?4¿ représentent chacun hydrogène, halogéno, alkyle en C¿1-6? ou hydroxyle; R?5¿ est alkyle en C¿1-6 ?ou aryle en C¿6-10?; et R est amino.

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