Quinazolin-4-yl- piperidine and cinnolin-4-yl- piperidine...

Details Quinazolin-4-yl- piperidine and cinnolin-4-yl- piperidine... Quinazolin-4-yl- piperidine and cinnolin-4-yl- piperidine...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/502 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2574685

The invention pertains to new piperidyl-substituted quinazoline and isoquínoline derivatives of formula (I) that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds that are selective inhibitors of PDE10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders.

L'invention concerne des nouveaux dérivés de la quinazoline et de l'isoquinoléine à substitution pipéridyle, de formule (I), servant d'inhibiteurs de la phosphodiestérase (PDE). L'invention porte également sur des composés qui sont des inhibiteurs sélectifs de PDE10. Elle se rapporte également à des intermédiaires pour la préparation desdits composés ; à des compositions pharmaceutiques comprenant lesdits composés, et à l'utilisation desdits composés dans des méthodes de traitement de certains troubles du système nerveux central ou autres.

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