Quinazoline-4-one ampa antagonists

Details Quinazoline-4-one ampa antagonists Quinazoline-4-one ampa antagonists

C - Chemistry, Metallurgy

07

D

C07D 239/88 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 239/80 (2006.01) C07D 239/91 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2239705

Disclosed are novel quinazolin-4-one derivatives of the formula I (see formula I) (in which the dashed line represents an optional double bond; A is a benzo or thieno ring; B is phenyl, pyridyl or pyrimidyl; X is N or CH; R1 is hydrogen or a substituent; R2 is a substituent such as halo; and R3 and R4 are hydrogen or a substituent), pharmaceutical compositions containing such compounds to treat neurodegenerative, psychotropic, and drug and alcohol induced central and peripheral nervous system disorders.

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