Quinazoline analogs as receptor tyrosine kinase inhibitors

Details Quinazoline analogs as receptor tyrosine kinase inhibitors Quinazoline analogs as receptor tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 239/94 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01) C07D 498/02 (2006.01)

Patent

CA 2535614

This invention provides quinazoline analogs of Formula (I): where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula (I) as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

L'invention concerne des analogues de quinazoline de la formule I, dans laquelle A est lié à au moins un des carbones à la position 5, 6, 7 ou 8 du noyau bicyclique, ledit noyau étant substitué par au maximum deux groupes R<3> indépendants. L'invention concerne également des procédés d'utilisation de composés de la formule I comme inhibiteurs du récepteur de la tyrosine kinase et dans le traitement de maladies hyperprolifératives telles que le cancer.

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