Quinazoline and pyridopyrimidine derivatives as p38 kinase...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/82 (2006.01) A61K 31/495 (2006.01) A61P 3/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2656507

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, s, T, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use such as treatment of kinase mediated diseases by administering the compounds of Formula I or compositions including the compounds of Formula I, and intermediates and processes useful for the preparation of compounds of Formula I.

La présente invention comprend une nouvelle classe de composés pouvant être employée dans le traitement prophylactique et thérapeutique de maladies faisant intervenir les protéines kinases, y compris l'inflammation et les états pathologiques associés. Les composés sont représentés par la Formule générale I, où A1, A2, B, s, T, R1, R2, R3 et R4 sont tels que définis dans la présente invention. La présente invention concerne également des compositions pharmaceutiques incluant un ou plusieurs composés représentés par la Formule I, leurs méthodes d'application, par exemple dans le traitement de maladies induites par des kinases par administration des composés de Formule I ou des compositions les incluant, ainsi que des intermédiaires et des procédés convenant pour la préparation de composés de Formule I.

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