Quinazoline antihypertensives

Details Quinazoline antihypertensives Quinazoline antihypertensives

C - Chemistry, Metallurgy

07

D

260/253

C07D 401/04 (2006.01) C07D 211/46 (2006.01)

Patent

CA 1131636

ABSTRACT Title: "Quinazoline Antihypertensives" Quinazoline antihypertensives of the formula: Image --- (I) and their pharmaceutically acceptable acid addition salts, wherein R is C1-C4 alXyl, benzyl or (C3-C6 cycloalkyl)methyl, R is C1-C4 alkyl, X is -CH2CH2- substltuted by a phenyl group and optianally by 1 or 2 methyl groups; and R2 is hydrogen, C1-C4 alkyl, or phenyl optionally substituted by 1 or 2 substltuents selected from C1-C4 alkyl, C1-C4 alkoxy, halogen, CF3, -CONR3R4 and -SO2NR3R4 wherein R3 and R4 each represent hydrogen or Cl-C4 alkyl; and processes for preparing the compounds of the formula (I); and pharmaceutical compositions containing them.

344714

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