Quinazoline based egfr inhibitors containing a zinc binding...

Details Quinazoline based egfr inhibitors containing a zinc binding... Quinazoline based egfr inhibitors containing a zinc binding...

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/517 (2006.01) A61P 35/04 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2662617

The present invention relates to quinazoline containing zinc-binding moiety based derivatives that have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

La présente invention concerne des dérivés à base de quinazoline contenant un fragment de liaison au zinc, qui présentent des propriétés améliorées et inattendues en tant qu'inhibiteurs de la tyrosine kinase du récepteur du facteur de croissance épidermique (EGFR-TK), ainsi que leur utilisation dans le traitement de maladies et de troubles associés à la EGFR-TK, notamment le cancer. Lesdits dérivés peuvent également faire office d'inhibiteurs d'HDAC.

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