Quinazoline derivatives

Details Quinazoline derivatives Quinazoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/505 (2006.01) A61P 37/06 (2006.01) C07D 215/54 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2378291

The invention concerns quinazoline derivatives of Formula (I) wherein Q1 includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3-X1- wherein X1 includes a direct bond and O and Q3 includes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of R2 and R3 is hydrogen or (1- 6C)alkyl; Z includes O, S and NH; and Q2 includes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of T cell mediated diseases or medical conditions in a warm-blooded animal.

L'invention concerne des dérivés de quinazoline de la formule (I) dans laquelle Q?1¿ comprend un cycle quinazoline facultativement remplacé par un groupe tel qu'halogéno, trifluorométhyle et cyano, ou un groupe de la formule: Q?3¿-X?1¿- dans laquelle X?1¿ contient une liaison directe ainsi que O et Q?3¿ contient aryle, aryl-alkyle (1-6C), hétérocyclyle et hétérocyclyl-alkyle (1-6C); chacun de R?2¿ et R?3¿ représente hydrogène ou alkyle (1-6C); Z contient O, S et NH; et Q?2¿ contient aryle et aryl-alkyle (1-3C) ou son sel acceptable sur le plan pharmaceutique; des procédés permettant leur préparation, des compositions pharmaceutiques les contenant et leur utilisation dans la fabrication d'un médicament destiné à être utilisé dans la prévention ou le traitement de maladies ou d'états médicaux médiés par les lymphocytes T chez un animal à sang chaud.

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