Quinazoline derivatives

Details Quinazoline derivatives Quinazoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 401/02 (2006.01) C07D 403/02 (2006.01) C07D 403/04 (2006.01) C07D 413/02 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2086968

The invention concerns quinazoline derivatives of the formula I (see fig. I) wherein m is 1, 2 or 3 and each R1 includes hydroxy, amino, carboxy, carbamoyl, ureido, (1-4C)alkoxycarbonyl, N-(1-4C)alkylcarbamoyl, N,N-di-[(1-4C)alkyl]carbamoyl, hydroxyamino, (1-4C)alkoxyamino, (2-4C)alkanoyloxyamino, trifluoromethoxy, (1-4C)alkyl, (1-4C)alkoxy and (1-3C)alkylenedioxy; n is 1 or 2 and each R2 includes hydrogen, hydroxy, halogeno, trifluoromethyl, amino, nitro, cyano and (1-4C)alkyl; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cancer.

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