A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/517 (2006.01) A61P 35/02 (2006.01) A61P 37/06 (2006.01) C07D 239/94 (2006.01)
Patent
CA 2342503
The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
L'invention concerne de nouveaux inhibiteurs de JAK-3, utiles pour le traitement de la leucémie et des lymphomes. Ces composés sont également utiles pour le traitement ou la prévention des cancers de la peau ainsi que des inflammations cutanées induites par les coups de soleil et les UVB. De plus, ces composés permettent d'éviter les effets immunosuppresseurs du rayonnement UVB et sont utiles pour le traitement ou la prévention des maladies auto-immunes, des inflammations et des rejets de greffes. L'invention concerne en outre des compositions pharmaceutiques contenant ces composants ainsi que des traitements associés.
Cetkovic Marina
Liu Xing-Ping
Malaviya Ravi
Uckun Faith M.
Goudreau Gage Dubuc
Parker Hughes Institute
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