Quinazoline derivatives

Details Quinazoline derivatives Quinazoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 239/88 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2384284

A compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2 or NR10 where R10 is hydrogen or C1-6 alkyl, and R1, R2, R3, R4, R5, R6, R7, R8 and R9 are various specified organic groups. These compounds are inhibitors of aurora 2 kinase, and are useful in the treatment of cancer.

L'invention concerne un composé correspondant à la formule (I) ou un de ses sels, esters ou amides. Dans la formule, X représente O ou S, S(O) ou S(O)¿2? ou NR?10¿, R?10¿ étant un groupe hydrogène ou C¿1-6? alkyle et R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, et R?9¿ représentant plusieurs groupes organiques spécifiés. Ces composés sont des inhibiteurs de l'aurora 2 kinase et sont utiles dans le traitement du cancer.

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