Quinazoline derivatives

Details Quinazoline derivatives Quinazoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 205/00 (2006.01) C07D 207/00 (2006.01) C07D 211/00 (2006.01) C07D 239/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2539049

The invention concerns quinazoline derivatives of the Formula (I); wherein each of R1, R2, W, X1, X2, Z, a and b are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti- proliferative effect. The quinazoline derivatives of Formula (I) are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.

L'invention concerne des dérivés de quinazoline représentés par la formule (I) dans laquelle chacun de R?1¿, R?2¿, W, X?1¿, X?2¿, Z, a et b possèdent les significations définies dans le descriptif; méthodes servant à préparer ces dérivés; compositions pharmaceutiques les contenant et leurs utilisations dans la préparation d'un médicament procurant un effet anti-prolifératif. Ces dérivés de quinazoline représentés par la formule (I) sont susceptibles d'être utiles pour le traitement de maladies, telles que certains cancers dans lesquels les tyrosines kinases du récepteur de erbB jouent un rôle, en particulier, la tyrosine kinase EGFR.

Affiliated with

Also associated with

Rating

Quinazoline derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Quinazoline derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinazoline derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1997520